THYMINELESS DEATH IN BACILLUS MEGATERIUM

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On the mechanism of thymineless death in Bacillus subtilis.

Thymineless death (TD), the loss by a thymine-requiring auxotroph of the ability to multiply after a period of thymine starvation, was first described1 in Escherichia coli 15T-, and was attributed to "unbalanced growth," the synthesis of RNA and protein in the absence of DNA synthesis. This phenomenon has been investigated in thymineless auxotrophs of a number of bacterial species: E. coli 15Ta...

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Thymineless death, at the origin

Thymineless death (TLD) in bacteria has been a focus of research for decades. Nevertheless, the advances in the last 5 years, with Escherichia coli as the model organism, have been outstanding. Independent research groups have presented compelling results that establish that the initiation of chromosome replication under thymine starvation is a key element in the scenario of TLD. Here we review...

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ژورنال

عنوان ژورنال: Journal of Bacteriology

سال: 1964

ISSN: 0021-9193,1098-5530

DOI: 10.1128/jb.87.5.1079-1086.1964